The EGL-13 SOX domain transcription factor affects the uterine pi cell lineages in Caenorhabditis elegans.
نویسندگان
چکیده
We isolated egl-13 mutants in which the pi cells of the Caenorhabditis elegans uterus initially appeared to develop normally but then underwent an extra round of cell division. The data suggest that egl-13 is required for maintenance of the pi cell fate.
منابع مشابه
Co-regulation by Notch and Fos is required for cell fate specification of intermediate precursors during C. elegans uterine development.
The Notch pathway is the key signal for many cell fate decisions in the nematode Caenorhabditis elegans including the uterine pi cell fate, crucial for a proper uterine-vulval connection and egg laying. Expression of the egl-13 SOX domain transcription factor is specifically upregulated upon induction of the pi lineage and not in response to other LIN-12/Notch-mediated decisions. We determined ...
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ورودعنوان ژورنال:
- Genetics
دوره 165 3 شماره
صفحات -
تاریخ انتشار 2003